Significance of Input Correlations in Striatal Function
نویسندگان
چکیده
منابع مشابه
Significance of Input Correlations in Striatal Function
The striatum is the main input station of the basal ganglia and is strongly associated with motor and cognitive functions. Anatomical evidence suggests that individual striatal neurons are unlikely to share their inputs from the cortex. Using a biologically realistic large-scale network model of striatum and cortico-striatal projections, we provide a functional interpretation of the special ana...
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An irreversible inhibitor of complex II in the mitochondria, 3-nitropropionic acid (3-NP), induces bilateral striatal lesions with many neuropathological features of Huntington’s disease (HD) in rats. It is widely used as a model of HD. Chronic systemic treatment of 3-NP for 4 days in rats (10, 15 and 20 mg/kg) caused a significant dose-dependent reduction in succinate dehydrogenase activity, w...
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ژورنال
عنوان ژورنال: PLoS Computational Biology
سال: 2011
ISSN: 1553-7358
DOI: 10.1371/journal.pcbi.1002254